2020-04-30 11:14:58.474 [main] INFO  com.nanostring.properties.loader.PropertiesLoader - Reading application properties...
2020-04-30 11:14:58.479 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the property files placed in resources
2020-04-30 11:14:58.480 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the following file: app.properties
2020-04-30 11:14:58.481 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the following file: local.properties
2020-04-30 11:14:58.481 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the following file: prod.properties
2020-04-30 11:14:58.482 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the files specified in parameters []
2020-04-30 11:14:58.482 [main] DEBUG com.nanostring.properties.loader.PropertiesLoader - Reading properties from the environment variables
2020-04-30 11:14:58.521 [main] INFO  com.nanostring.pluto.pathways.core.db.PathwayDB - Loading pathways database from src/main/resources/pathways.db
2020-04-30 11:14:58.670 [main] INFO  com.nanostring.pluto.pathways.core.db.PathwayDB - Successfully imported the pathway database. Pathways present: 21012.
2020-04-30 11:14:58.833 [main] DEBUG spark.route.Routes - Adds route: before, +/*paths, spark.FilterImpl$1@5db6b9cd
2020-04-30 11:14:58.834 [main] DEBUG spark.route.Routes - Adds route: after, +/*paths, spark.FilterImpl$1@7857fe2
2020-04-30 11:14:58.834 [main] DEBUG spark.route.Routes - Adds route: options, /*, spark.RouteImpl$1@446a1e84
2020-04-30 11:14:58.862 [main] DEBUG spark.route.Routes - Adds route: get, /api/pathways/version, spark.ResponseTransformerRouteImpl$1@6ca18a14
2020-04-30 11:14:58.864 [main] DEBUG spark.route.Routes - Adds route: post, /api/coverage/table, spark.ResponseTransformerRouteImpl$1@2462cb01
2020-04-30 11:14:58.864 [main] DEBUG spark.route.Routes - Adds route: post, /api/coverage/spidermap, spark.ResponseTransformerRouteImpl$1@77659b30
2020-04-30 11:14:58.865 [main] DEBUG spark.route.Routes - Adds route: post, /api/coverage/genePathwayCount, spark.ResponseTransformerRouteImpl$1@1ec9bd38
2020-04-30 11:14:58.865 [main] DEBUG spark.route.Routes - Adds route: post, /api/coverage/singlePathway, spark.ResponseTransformerRouteImpl$1@6f8e8894
2020-04-30 11:14:58.866 [main] DEBUG spark.route.Routes - Adds route: post, /api/coverage/pathwayGeneMap, spark.ResponseTransformerRouteImpl$1@e25951c
2020-04-30 11:14:58.867 [main] DEBUG spark.route.Routes - Adds route: get, /api/pathways/:species, spark.ResponseTransformerRouteImpl$1@19976a65
2020-04-30 11:14:58.868 [main] DEBUG spark.route.Routes - Adds route: post, /api/analysis/fgsea, spark.ResponseTransformerRouteImpl$1@4bc222e
2020-04-30 11:14:58.927 [Thread-1] INFO  spark.embeddedserver.jetty.EmbeddedJettyServer - == Spark has ignited ...
2020-04-30 11:14:58.927 [Thread-1] INFO  spark.embeddedserver.jetty.EmbeddedJettyServer - >> Listening on 0.0.0.0:8480
2020-04-30 11:24:49.891 [qtp772047381-32] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 11:24:50.074 [qtp772047381-32] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 11:24:50.106 [qtp772047381-32] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:02:29.920 [qtp772047381-36] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:02:30.123 [qtp772047381-36] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:02:30.143 [qtp772047381-36] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:05:34.931 [qtp772047381-26] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:05:35.125 [qtp772047381-26] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:05:35.136 [qtp772047381-26] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:07:06.815 [qtp772047381-27] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:07:06.979 [qtp772047381-27] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:07:06.989 [qtp772047381-27] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:07:19.204 [qtp772047381-23] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:07:19.332 [qtp772047381-23] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:07:19.340 [qtp772047381-23] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:14:05.849 [qtp772047381-43] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:14:05.849 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:14:06.285 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:14:06.305 [qtp772047381-43] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:15:55.923 [qtp772047381-41] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:15:55.923 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:15:56.189 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a spider map.
2020-04-30 12:15:56.193 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 8572 gene(s) from id(s)
2020-04-30 12:15:56.423 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:15:56.429 [qtp772047381-41] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:15:56.564 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27222 gene-pathway match(es) from gene id(s)
2020-04-30 12:15:56.614 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathways from ids
2020-04-30 12:15:56.649 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1736 pathways
2020-04-30 12:15:56.696 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Finished generating spider map data
2020-04-30 12:15:56.709 [qtp772047381-43] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:16:34.195 [qtp772047381-40] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:16:34.195 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:16:34.410 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a spider map.
2020-04-30 12:16:34.410 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 8572 gene(s) from id(s)
2020-04-30 12:16:34.732 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:16:34.737 [qtp772047381-40] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:16:34.835 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27222 gene-pathway match(es) from gene id(s)
2020-04-30 12:16:34.865 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathways from ids
2020-04-30 12:16:34.897 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1736 pathways
2020-04-30 12:16:34.899 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Finished generating spider map data
2020-04-30 12:16:34.902 [qtp772047381-41] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:17:14.384 [qtp772047381-26] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:17:14.385 [qtp772047381-26] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:17:14.596 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a spider map.
2020-04-30 12:17:14.597 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 8572 gene(s) from id(s)
2020-04-30 12:17:14.898 [qtp772047381-26] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:17:14.902 [qtp772047381-26] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:17:14.989 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27222 gene-pathway match(es) from gene id(s)
2020-04-30 12:17:15.003 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathways from ids
2020-04-30 12:17:15.035 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1736 pathways
2020-04-30 12:17:15.036 [qtp772047381-46] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Finished generating spider map data
2020-04-30 12:17:15.039 [qtp772047381-46] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:18:05.893 [qtp772047381-43] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:18:05.893 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:18:06.089 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a spider map.
2020-04-30 12:18:06.089 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 8572 gene(s) from id(s)
2020-04-30 12:18:06.457 [qtp772047381-43] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:18:06.461 [qtp772047381-43] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:18:06.540 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27222 gene-pathway match(es) from gene id(s)
2020-04-30 12:18:06.552 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathways from ids
2020-04-30 12:18:06.587 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1736 pathways
2020-04-30 12:18:06.588 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Finished generating spider map data
2020-04-30 12:18:06.590 [qtp772047381-40] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:21:36.335 [qtp772047381-45] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:21:36.458 [qtp772047381-45] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:21:36.466 [qtp772047381-45] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:21:54.435 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a coverage table.
2020-04-30 12:21:54.436 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 8572 gene(s) from id(s)
2020-04-30 12:21:54.564 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27222 gene-pathway match(es) from gene id(s)
2020-04-30 12:21:54.658 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathways from ids
2020-04-30 12:21:54.688 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1736 pathways
2020-04-30 12:21:54.689 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1736 pathway(s) by id(s)
2020-04-30 12:21:54.914 [qtp772047381-41] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained gene(s) for 1736 pathway(s)
2020-04-30 12:21:55.129 [qtp772047381-41] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:22:08.121 [qtp772047381-39] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:22:08.267 [qtp772047381-39] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:22:08.274 [qtp772047381-39] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:22:08.487 [qtp772047381-39] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:22:08.635 [qtp772047381-39] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:22:08.642 [qtp772047381-39] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:23:12.790 [qtp772047381-50] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:23:12.929 [qtp772047381-50] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:23:12.944 [qtp772047381-50] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:24:09.645 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:24:09.775 [qtp772047381-40] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:24:09.782 [qtp772047381-40] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:38:36.292 [qtp772047381-56] DEBUG spark.Request - matchedPart: :species = Homo sapiens
2020-04-30 12:38:36.292 [qtp772047381-56] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting all pathways for species 'Homo sapiens'
2020-04-30 12:38:36.370 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Generating pathway data for a spider map.
2020-04-30 12:38:36.371 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1821 gene(s) from id(s)
2020-04-30 12:38:36.873 [qtp772047381-56] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Pathway dump finished.
2020-04-30 12:38:36.886 [qtp772047381-56] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:38:36.934 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:38:36.943 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting 1738 pathways from ids
2020-04-30 12:38:36.975 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 1738 pathways
2020-04-30 12:38:36.975 [qtp772047381-57] DEBUG com.nanostring.pluto.pathways.core.bl.workflow.DefaultCoverageWorkflow - Finished generating spider map data
2020-04-30 12:38:36.977 [qtp772047381-57] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression
2020-04-30 12:44:10.583 [qtp772047381-63] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Getting data/pathway for 1825 gene(s) from id(s)
2020-04-30 12:44:10.715 [qtp772047381-63] DEBUG com.nanostring.pluto.pathways.core.db.PathwayDB - Obtained 27314 gene-pathway match(es) from gene id(s)
2020-04-30 12:44:10.722 [qtp772047381-63] INFO  com.nanostring.pluto.pathways.Main - Enabled http response compression